Alper K R, Chabot R J, Kim A H, Prichep L S, John E R
Department of Psychiatry, New York University Medical Center, NY.
Psychiatry Res. 1990 Dec;35(2):95-105. doi: 10.1016/0925-4927(90)90013-v.
Evidence for a distinctive syndrome of neuroadaptation in cocaine dependence has accumulated from behavioral, neurophysiological, and preclinical and clinical pharmacological studies. The authors report on the results of a preliminary investigation of the quantitative electroencephalographic (QEEG) correlates of severe DSM-III-R crack cocaine dependence in seven patients abstinent from cocaine for 1 to 68 days. The major QEEG finding was increased absolute and relative alpha power. Increased alpha power has also been reported in multiple previous studies of depressed patients. This series of crack-dependent patients showed significant depressive morbidity; four patients attempted suicide subsequent to initiating their use of crack and the group mean (+/- SD) Beck Depression Scale score was 18.9 (+/- 6.5). These results complement other studies that support the concept of neuroadaptation to chronic cocaine exposure. Prospective studies correlating QEEG measures with subsequent response to pharmacological interventions for cocaine dependence should be considered.
行为学、神经生理学以及临床前和临床药理学研究均已积累了证据，证明可卡因依赖存在一种独特的神经适应综合征。作者报告了一项初步调查的结果，该调查针对7名已戒除可卡因1至68天、患有严重DSM-III-R快克可卡因依赖的患者，研究其定量脑电图（QEEG）相关性。QEEG的主要发现是绝对和相对α波功率增加。在先前多项针对抑郁症患者的研究中也报告了α波功率增加的情况。这组快克依赖患者表现出显著的抑郁发病率；4名患者在开始使用快克后企图自杀，且该组的贝克抑郁量表平均得分（±标准差）为18.9（±6.5）。这些结果补充了其他支持慢性可卡因暴露神经适应概念的研究。应考虑开展前瞻性研究，将QEEG测量结果与随后对可卡因依赖的药物干预反应相关联。
