Prichep L S, Alper K, Kowalik S C, Rosenthal M
Department of Psychiatry, New York University Medical Center, NY 10016, USA.
J Addict Dis. 1996;15(4):39-53. doi: 10.1300/J069v15n04_03.
This paper presents an overview of the quantitative electrophysiological (QEEC) research on cocaine dependence conducted at Brain Research Laboratories of New York University Medical Center. These studies have demonstrated that subjects with DSM-III-R cocaine dependence (without dependence on any other substance) evaluated in the withdrawal state, have replicable abnormalities in brain function when evaluated at baseline (approximately 5 to 10 days after last crack cocaine use), which are still seen at one and six month follow-up evaluations. These abnormalities were characterized by significant excess of relative alpha power and deficit of absolute and relative delta and theta power. Abnormalities were greater in anterior than posterior regions, and disturbances in interhemispheric relationships were also observed. In addition, QEEC subtypes were identified within the population of cocaine dependent subjects at baseline, and these subtypes were found to be significantly related to subsequent length of stay in treatment. The relationship between these QEEG findings and the neuropharmacology of cocaine dependence is discussed.
本文概述了纽约大学医学中心脑研究实验室开展的关于可卡因依赖的定量电生理学（QEEC）研究。这些研究表明，符合《精神疾病诊断与统计手册第三版修订本》（DSM-III-R）可卡因依赖标准（不依赖任何其他物质）且处于戒断状态的受试者，在基线评估时（末次使用快克可卡因后约5至10天）脑功能存在可重复的异常，在1个月和6个月的随访评估中仍可观察到。这些异常表现为相对α波功率显著过高，绝对和相对δ波以及θ波功率不足。前部区域的异常比后部区域更明显，并且还观察到半球间关系紊乱。此外，在基线时可卡因依赖受试者群体中识别出了QEEC亚型，发现这些亚型与后续治疗住院时间显著相关。本文还讨论了这些定量脑电图研究结果与可卡因依赖神经药理学之间的关系。
