Meechan J G, Thomason J M
Department of Oral and Maxillofacial Surgery, University of Newcastle upon Tyne, England.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999 Mar;87(3):362-5. doi: 10.1016/s1079-2104(99)70224-6.
The purpose of this volunteer clinical trial was to compare the effects of 5% lidocaine ointment and EMLA cream on the discomfort associated with intraligamentary injections.
A double-blind, split mouth study was conducted. Each of 10 healthy volunteers had 5% lidocaine and EMLA cream applied to the maxillary premolar buccal gingiva for 5 minutes before the administration of an intraligamentary injection. Discomfort during the injection was assessed through use of a visual analog scale. Data were analyzed by means of Student paired and unpaired t tests.
Injection discomfort on the side on which EMLA cream was applied was significantly less than on the lidocaine side (t = 2.32, P < .05).
EMLA cream reduced the discomfort associated with intraligamentary injections.
本志愿者临床试验的目的是比较5%利多卡因软膏和复方利多卡因乳膏对韧带内注射相关不适的影响。
进行了一项双盲、双侧对照研究。10名健康志愿者中的每一位在进行韧带内注射前，将5%利多卡因和复方利多卡因乳膏涂于上颌前磨牙颊侧牙龈5分钟。通过视觉模拟量表评估注射过程中的不适。数据采用学生配对和非配对t检验进行分析。
涂抹复方利多卡因乳膏一侧的注射不适明显低于利多卡因一侧（t = 2.32，P < 0.05）。
复方利多卡因乳膏减轻了韧带内注射相关的不适。
