Honnens de Lichtenberg M, Krogh J, Rye B, Miskowiak J
Department of Urology, Bispebjerg Hospital, University of Copenhagen, Denmark.
J Urol. 1992 Jan;147(1):98-9. doi: 10.1016/s0022-5347(17)37144-6.
Two paired randomized trials testing topical anesthesia with a eutetic mixture of local anesthetics (EMLA cream*) in vasectomy were performed. In 1 trial EMLA cream was applied on 1 side of the scrotum, while infiltration anesthesia into the skin and subcutaneous tissue with mepivacaine was used on the contralateral side. All but 1 of the 13 patients (p less than 0.05) preferred infiltration anesthesia because of pain as the incision reached the subcutaneous tissue. In the other trial 29 patients received EMLA cream on 1 side of the scrotum before bilateral mepivacaine infiltration. There was significantly less pain on the sides with the anesthetic cream (p less than 0.001). Many patients would pay the price of the cream. In conclusion, EMLA cream cannot replace but it can supplement infiltration anesthesia during vasectomy.
进行了两项配对随机试验，测试复方利多卡因乳膏（EMLA乳膏*）用于输精管结扎术中的局部麻醉效果。在一项试验中，将EMLA乳膏涂抹于阴囊一侧，而对侧则采用甲哌卡因对皮肤和皮下组织进行浸润麻醉。13名患者中除1人外（p<0.05），其余患者均因切口到达皮下组织时疼痛而更倾向于浸润麻醉。在另一项试验中，29名患者在双侧甲哌卡因浸润前，于阴囊一侧涂抹EMLA乳膏。涂抹麻醉乳膏一侧的疼痛明显减轻（p<0.001）。许多患者愿意支付乳膏的费用。总之，EMLA乳膏不能替代浸润麻醉，但可在输精管结扎术中作为浸润麻醉的补充。
