Meechan J G, Donaldson D
Department of Oral Surgery, University of Newcastle upon Tyne.
ASDC J Dent Child. 1994 Jul-Aug;61(4):260-2.
The use of 5 percent EMLA (an eutectic mixture of local anesthetics comprised of a mixture of prilocaine and lidocaine) as an intraoral topical anesthetic in children has been assessed in a clinical investigation. In a split-mouth study in twenty children there was no difference in the efficacy of EMLA and 5 percent lidocaine ointment in alleviating the pain of maxillary buccal infiltration injections of local anesthetics. EMLA did not differ significantly from placebo in the changes in pulpal responses of maxillary primary teeth to electrical stimulation before and after application in a double-blind split-mouth study in twenty children.
在一项临床研究中,已对5%的复方利多卡因乳膏(一种由丙胺卡因和利多卡因混合而成的局部麻醉药共熔混合物)作为儿童口腔内局部麻醉剂的使用情况进行了评估。在一项针对20名儿童的双侧对照研究中,复方利多卡因乳膏和5%利多卡因软膏在减轻上颌颊侧浸润注射局部麻醉药的疼痛方面疗效无差异。在一项针对20名儿童的双盲双侧对照研究中,复方利多卡因乳膏在上颌乳齿应用前后对电刺激的牙髓反应变化方面与安慰剂无显著差异。