Goldin B, Dwyer J, Gorbach S L, Gordon W, Swenson L
Am J Clin Nutr. 1978 Oct;31(10 Suppl):S136-S140. doi: 10.1093/ajcn/31.10.S136.
The bacterial enzymes beta-glucuronidase, azoreductase, and nitroreductase, all implicated in the etiology of colon cancer, were measured in the fecal microflora of rats and humans. The effect of a high-beef diet and advanced age on the activities of these microbial enzymes were determined in the rat. Rats shifted from a grain to a meat diet showed a 1.5- to 2.5-fold increase in activity of all three fecal enzymes. Animals over 20 months of age, consuming a meat diet, showed a further increase in fecal beta-glucuronidase activity, while the levels of all three microbial enzymes increased in old rats fed a grain diet. Fecal microbial enzyme activities were also measured in humans eating a diet supplemented with bran or wheat germ. Humans receiving fiber supplements consisting of 30 g of bran or wheat germ added to their customary diets did not show significant changes in fecal enzyme activity.
对大鼠和人类粪便微生物群中与结肠癌病因均有关的细菌酶β-葡萄糖醛酸酶、偶氮还原酶和硝基还原酶进行了测定。在大鼠中确定了高牛肉饮食和老龄对这些微生物酶活性的影响。从谷物饮食转变为肉类饮食的大鼠，所有三种粪便酶的活性均增加了1.5至2.5倍。食用肉类饮食的20个月以上动物，其粪便β-葡萄糖醛酸酶活性进一步增加，而喂食谷物饮食的老龄大鼠中所有三种微生物酶的水平均升高。还对食用添加了麸皮或小麦胚芽的饮食的人类粪便微生物酶活性进行了测定。在其日常饮食中添加30克麸皮或小麦胚芽组成的纤维补充剂的人类，其粪便酶活性未显示出显著变化。
