Paradelis A G, Douboyas J, Stathopoulos G, Grigoriadou-Edipides A, Triantaphylidis C, Papapanagiotou J
Antimicrob Agents Chemother. 1978 Sep;14(3):514-5. doi: 10.1128/AAC.14.3.514.
The antimicrobial activity of kanamycin, kanendomycin, gentamicin, amikacin, sisomicin, and dibekacin against 200 strains of Pseudomonas aeruginosa was compared. Dibekacin was found to be the most active against the tested organisms, whereas the other aminoglycoside antibiotics fell in the following order of diminishing antibacterial potency: amikacin, sisomicin, gentamicin, kanendomycin, and kanamycin. Seven strains showed high-level resistance to gentamicin (minimal inhibitory concentration, 400 mug/ml), and two of them were also resistant to amikacin and sisomicin (minimal inhibitory concentration, 75 mug/ml). The minimal inhibitory concentration of dibekacin for these seven strains was 0.625 mug/ml.
比较了卡那霉素、卡那内多霉素、庆大霉素、阿米卡星、西索米星和地贝卡星对200株铜绿假单胞菌的抗菌活性。发现地贝卡星对受试菌活性最强，而其他氨基糖苷类抗生素的抗菌效力按以下递减顺序排列：阿米卡星、西索米星、庆大霉素、卡那内多霉素和卡那霉素。7株菌对庆大霉素表现出高水平耐药（最低抑菌浓度为400μg/ml），其中2株对阿米卡星和西索米星也耐药（最低抑菌浓度为75μg/ml）。地贝卡星对这7株菌的最低抑菌浓度为0.625μg/ml。
