Hulshof J, Ponnamperuma C
Orig Life. 1976 Aug;7(3):197-24. doi: 10.1007/BF00926938.
Biopolymers are formed by dehydration-type condensation reactions. In aqueous solutions dehydration reactions are very unlikely to happen spontaneously. However, coupling of dehydration-condensation to the hydrolysis of condensing agents could facilitate the synthesis of biopolymers in an aqueous solution. The literature shows that the peptides, nucleosides, nucleotides and oligonucleotides can be formed in this way. A careful study of the literature pertaining to prebiotic condensing agents was conducted in order to determine the most plausible prebiotic synthesis of biopolymers. The condensing agents taken into consideration are cyanamide, carbodimide, dicyanamide, dicyandiamide, hydrogen-cyanide-tetramer, cyanogen and the linear- and cyclic polyphosphates. From both a chemical as well as biological point of view the polyphosphates appear to be the most plausible general prebiotic condensing agent.
生物聚合物是通过脱水型缩合反应形成的。在水溶液中，脱水反应极不可能自发发生。然而，将脱水缩合与缩合剂的水解相偶联可以促进生物聚合物在水溶液中的合成。文献表明，肽、核苷、核苷酸和寡核苷酸都可以通过这种方式形成。为了确定最合理的生物聚合物的益生元合成方式，对与益生元缩合剂相关的文献进行了仔细研究。所考虑的缩合剂有氰胺、碳二亚胺、双氰胺、二氰二胺、氰化氢四聚体、氰和线性及环状多磷酸盐。从化学和生物学角度来看，多磷酸盐似乎是最合理的一般益生元缩合剂。
