Bendtsen P, Bjurulf P, Trell E, Lindström F, Larsson J E
Department of Community Medicine, University of Linköping, Sweden.
Pharmacoeconomics. 1994 May;5(5):399-407. doi: 10.2165/00019053-199405050-00006.
This study analyses patterns of treatment offered to individuals with a clinical diagnosis of rheumatoid arthritis (RA). A cross-sectional investigation was carried out in 321 patients (aged greater than 16 years) fulfilling the 1958 American Rheumatism Association (ARA) criteria for RA. Medical records were scrutinised retrospectively for information about medical, surgical and other treatments during a 5-year period (1982 to 1986). All patients had received medical treatment, but a large number had discontinued drug therapy because of adverse effects or lack of efficacy. 45.9% of the individuals were receiving 1 drug at the time of the survey, 33.8% were on 2 drugs, 11.7% were on 3 or 4 drugs, and 8.6% were not receiving any medication. Nearly 50% of the patients had had various kinds of surgical procedures performed. The clinical manifestation of the disease, as measured by the number of ARA criteria fulfilled, showed a linear correlation to nearly all medical and surgical treatments. A primary healthcare physician was the basic contact person for 90% of the patients, but in addition 70% of the participants had been examined at sometime by a rheumatological specialist. The study confirms our expectations that patients with RA receive numerous pharmaceutical and other treatments. Even patients with mild and/or early disease (probable RA) had received a considerable amount of treatment. Qualified specialised care was also provided despite the distance to a university referral centre.(ABSTRACT TRUNCATED AT 250 WORDS)
本研究分析了针对临床诊断为类风湿性关节炎(RA)患者的治疗模式。对321名符合1958年美国风湿病协会(ARA)类风湿性关节炎标准的患者(年龄大于16岁)进行了横断面调查。回顾性审查医疗记录,以获取有关5年期间(1982年至1986年)医疗、手术及其他治疗的信息。所有患者均接受过药物治疗,但许多患者因不良反应或疗效不佳而停止了药物治疗。在调查时,45.9%的患者正在接受1种药物治疗,33.8%的患者使用2种药物,11.7%的患者使用3或4种药物,8.6%的患者未接受任何药物治疗。近50%的患者接受过各种外科手术。根据满足的ARA标准数量衡量,疾病的临床表现与几乎所有医疗和外科治疗均呈线性相关。90%的患者的基本联系人是初级保健医生,但此外,70%的参与者曾在某个时候接受过风湿病专科医生的检查。该研究证实了我们的预期,即类风湿性关节炎患者接受了大量药物及其他治疗。即使是患有轻度和/或早期疾病(可能为类风湿性关节炎)的患者也接受了大量治疗。尽管距离大学转诊中心较远,但仍提供了合格的专科护理。(摘要截选至250字)