Black R J, Zardiackas L D, Teasdall R, Hughes J L
Orthopaedic Surgery, University of Mississippi Medical Center, Jackson.
Clin Mater. 1990;6(3):251-64. doi: 10.1016/0267-6605(90)90062-z.
The need for an animal model to test bone graft materials simulating a weight bearing clinical situation is identified. The concept, design and operative detail of a new model is described. This model involved the creation of a mid-diaphyseal wedge defect in the femur of the adult beagle which separated both cortices, plating with a six-hole dynamic compression plate, and allowed immediate full weight bearing. At six months plates were removed and immediate weight bearing was allowed for an additional six months to sacrifice. The initial animal project utilizing this model to evaluate a hydroxyapatite based synthetic graft material was performed using 12 dogs. In addition to the operative procedure, the retrieval testing in torsion of 12 healed grafted bones and their 12 contralateral unoperated controls is described and evaluated. Results showed no statistically significant difference between the torsional strength of test and control femurs (p less than or equal to 0.05). In addition, the future development of the model is discussed.
人们认识到需要一种动物模型来测试模拟负重临床情况的骨移植材料。本文描述了一种新模型的概念、设计和手术细节。该模型包括在成年比格犬的股骨干中段制造一个楔形骨缺损，该缺损将两侧皮质骨分开，用六孔动力加压钢板固定，并允许立即完全负重。在六个月时取出钢板，并允许立即负重额外六个月后处死动物。最初利用该模型评估一种基于羟基磷灰石的合成移植材料的动物实验使用了12只狗。除了手术过程外，还描述并评估了对12根愈合的移植骨及其12根对侧未手术对照骨进行的扭转回收测试。结果显示，测试股骨和对照股骨的抗扭强度之间无统计学显著差异（p小于或等于0.05）。此外，还讨论了该模型的未来发展。
