Moore D C, Chapman M W, Manske D
J Orthop Res. 1987;5(3):356-65. doi: 10.1002/jor.1100050307.
The effectiveness of a sintered hydroxyapatite-tricalcium phosphate (HA-TCP) ceramic in bridging large diaphyseal defects in the canine ulna was studied. One-hundred percent morselized HA-TCP, a 50:50 mixture of morselized HA-TCP, and autogenous cancellous bone, and 100% autogenous cancellous bone were used to bridge 2.5-cm defects in the left ulnae of three groups of six dogs each. At 24 weeks the ulnae were explanted and studied by radiography, microradiography, mechanical testing, and histology. Pure HA/TCP was not osteoinductive, and four of six ulnae in this group progressed to a fibrous nonunion. The HA/TCP-cancellous bone mixture and pure cancellous bone were approximately equal in effect, leading to good callus formation at 4 weeks and strong bony union by 24 weeks, with no evidence of bioincompatibility. Morselized HA/TCP promises to be useful as a graft extender when mixed with autogenous cancellous bone.
研究了一种烧结羟基磷灰石-磷酸三钙（HA-TCP）陶瓷在桥接犬尺骨大段骨干缺损方面的有效性。分别用100%碎粒状HA-TCP、碎粒状HA-TCP与自体松质骨按50:50比例混合的材料以及100%自体松质骨，对三组实验犬（每组6只）的左尺骨2.5厘米缺损进行桥接。24周时取出尺骨，通过X线摄影、显微放射摄影、力学测试和组织学进行研究。纯HA/TCP无骨诱导性，该组6只尺骨中有4只发展为纤维性骨不连。HA/TCP-松质骨混合物和纯松质骨的效果大致相同，4周时形成良好的骨痂，24周时实现牢固的骨愈合，且无生物不相容性迹象。碎粒状HA/TCP与自体松质骨混合时有望作为一种移植增强材料发挥作用。
