Loh I H, Lin H L, Chu C C
Advanced Surface Technology, Inc., Billerica, Massachusetts.
J Appl Biomater. 1992 Summer;3(2):131-46. doi: 10.1002/jab.770030209.
The aim of the study was to examine the feasibility of using plasma surface modification technology to alter the hydrolytic degradation rate of commercial synthetic absorbable sutures. Size 2-0 Dexon, Vicryl, PDSII, and Maxon sutures were tested. They were treated by two different surface modification techniques: parylene deposition and plasma gases (Methane, trimethylsilane, and tetrafluoroethene). The thickness of surface treatment ranged from 200 to 1000 A. The treated sutures were subject to in vitro hydrolytic degradation in phosphate buffer of pH = 7.4 at 37 degrees C for up to 120 days. The tensile breaking strength, weight loss, surface wettability, bending stiffness, and surface morphology were evaluated. The results indicated that the concept of plasma surface treatment for altering the hydrolytic degradation of synthetic absorbable sutures was feasible, and the level of improvement depended on the type of sutures, the treatment conditions, and the duration of hydrolysis. Vicryl and PDSII sutures showed overall the best improvement in tensile strength retention among the four commercial sutures. Dexon and Maxon sutures, however, exhibited only marginal improvement. The observed improvement in tensile strength retention appeared to be related to the increasing hydrophobicity of the sutures. The surface treatments did not adversely affect the bending stiffness of the sutures and no visible surface morphological changes were observed. Refinements and optimization of the surface treatment conditions are needed for achieving the maximum advantage of the proposed concept, particularly shielding the harmful effect of uv during plasma treatment.
本研究的目的是检验使用等离子体表面改性技术来改变商业合成可吸收缝线水解降解速率的可行性。对2-0号的 Dexon、Vicryl、PDSII和Maxon缝线进行了测试。它们采用两种不同的表面改性技术进行处理：聚对二甲苯沉积和等离子体气体（甲烷、三甲基硅烷和四氟乙烯）。表面处理的厚度范围为200至1000埃。将处理后的缝线在37℃、pH = 7.4的磷酸盐缓冲液中进行体外水解降解，长达120天。评估了拉伸断裂强度、重量损失、表面润湿性、弯曲刚度和表面形态。结果表明，等离子体表面处理以改变合成可吸收缝线水解降解的概念是可行的，改善程度取决于缝线类型、处理条件和水解持续时间。在四种商业缝线中，Vicryl和PDSII缝线在拉伸强度保持方面总体上改善最佳。然而，Dexon和Maxon缝线仅表现出微小的改善。观察到的拉伸强度保持的改善似乎与缝线疏水性的增加有关。表面处理对缝线的弯曲刚度没有不利影响，并且未观察到明显的表面形态变化。为了实现所提出概念的最大优势，特别是在等离子体处理期间屏蔽紫外线的有害影响，需要对表面处理条件进行改进和优化。
