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慢性胰腺炎的胰腺切除术

Pancreatectomy for chronic pancreatitis.

作者信息

Frey C F, Child C G, Fry W

出版信息

Ann Surg. 1976 Oct;184(4):403-13. doi: 10.1097/00000658-197610000-00002.

Abstract

Of one hundred and forty-nine patients (101 male and 48 female) 4-67 years of age, 117 were alcoholics and underwent pancreatectomy because of episodic or continuous abdominal pain or complications or chronic pancreatitis. Nineteen patients underwent pancreaticoduodenectomy, seventy-seven 80-95% distal resection, anf fifty-three 40-80% distal pancreatic resection. There were 3 operative death and 30 late deaths 6 months to 11 years post pancreatectomy. Twenty-one patients were lost to followup, 1 to 11 years post pancreatectomy. Ninety-five patients are known to be alive, 4 of whom are institutionalized. Indications for pancreatectomy in addition to abdominal pain include recurrent or multiple pseudocysts, failure to relieve pain after decompression of a pseudocyst, pseudoaneurysm of the visceral arteries associated with a pseudocyst, recurrent attacks of pancreatitis unrelived by non-resective operations, duodenal stenosis and left side portal hypertension. The choice between pancreaticoduodenectomy or distal resection of 40-80% or 80-95% of the pancreas should be based on the principle site of inflammation whether proximal or distal in the gland, the size of the common bile duct, the ability to rule out carcinoma, and the anticipated deficits in exocrine and endocrine function. The risk of diabetes is very significant after 80-95% distal resection and of steatorrhea after pancreaticoduodenectomy. When the disease process can be encompassed by 40-80% distal pancreatectomy this is the procedure of choice.

摘要

149例年龄在4至67岁的患者(男性101例,女性48例)中,117例为酗酒者,因发作性或持续性腹痛、并发症或慢性胰腺炎接受了胰腺切除术。19例患者接受了胰十二指肠切除术,77例接受了80 - 95%的远端切除术,53例接受了40 - 80%的远端胰腺切除术。胰腺切除术后有3例手术死亡和30例晚期死亡,时间为术后6个月至11年。21例患者在胰腺切除术后1至11年失访。已知95例患者存活,其中4例住院治疗。除腹痛外,胰腺切除术的指征还包括复发性或多发性假性囊肿、假性囊肿减压后疼痛未缓解、与假性囊肿相关的内脏动脉假性动脉瘤、非切除性手术无法缓解的复发性胰腺炎发作、十二指肠狭窄和左侧门静脉高压。胰十二指肠切除术或胰腺40 - 80%或80 - 95%的远端切除术的选择应基于炎症在胰腺中的主要部位(近端或远端)、胆总管的大小、排除癌症的能力以及预期的外分泌和内分泌功能缺陷。80 - 95%远端切除术后糖尿病风险非常高,胰十二指肠切除术后脂肪泻风险高。当疾病进程可通过40 - 80%远端胰腺切除术解决时,这是首选的手术方式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/323b/1345429/ff0313ba130d/annsurg00272-0027-a.jpg

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