Bryant D H, Burns M W
Clin Allergy. 1976 Nov;6(6):523-32. doi: 10.1111/j.1365-2222.1976.tb01937.x.
The aim of this study was to examine the proposal that the magnitude of the response of the bronchi to an immediate allergic reaction depends not only on the degree of sensitization of the bronchi by allergen specific IgE antibody but also on the reactivity of the bronchi to the vasoactive mediators which are released during immediate allergic reactions. This was done by determining the bronchial reactivity to Dermatophagoides pteronyssinus and to histamine of both symptomatic and asymptomatic groups of atopic subjects who had comparable serum levels of D. pteronyssinus specific IgE. Positive bronchial responses to the D. pteronyssinus extract were recorded with both the symptomatic and asymptomatic subjects, the mean bronchial threshold dose of allergen being significantly higher in the asymptomatic than in the asthmatic patients. There was a highly significant correlation between the serum level of allergen specific IgE and the bronchial threshold dose of allergen extract and also between the bronchial threshold dose of allergen extract and of histamine in all groups of subjects. The ability to predict bronchial reactivity to the allergen from the serum level of allergen specific IgE within each group was significantly better if the bronchial reactivity to histamine was included in the correlation analysis. This supports the hypothesis that whether a particular subject who is producing specific IgE antibody will develop symptoms on the inhalation of that allergen depends not only on the amount of allergen which he inhales and on the degree of sensitization of his bronchi but also on the reactivity of his bronchi to the vasoactive mediators which are released by allergen-IgE interaction.
支气管对速发型过敏反应的反应程度不仅取决于变应原特异性IgE抗体使支气管致敏的程度，还取决于支气管对速发型过敏反应期间释放的血管活性介质的反应性。通过测定有可比性的血清中粉尘螨特异性IgE水平的特应性受试者有症状组和无症状组对粉尘螨和组胺的支气管反应性来进行此项研究。有症状和无症状受试者对粉尘螨提取物均出现阳性支气管反应，无症状受试者变应原的平均支气管阈值剂量显著高于哮喘患者。在所有受试者组中，变应原特异性IgE的血清水平与变应原提取物的支气管阈值剂量之间以及变应原提取物和组胺的支气管阈值剂量之间均存在高度显著的相关性。如果在相关性分析中纳入对组胺的支气管反应性，则根据每组变应原特异性IgE的血清水平预测对变应原的支气管反应性的能力会显著提高。这支持了以下假说：产生特异性IgE抗体的特定受试者吸入该变应原时是否会出现症状，不仅取决于他吸入的变应原量及其支气管的致敏程度，还取决于其支气管对变应原-IgE相互作用释放的血管活性介质的反应性。
