Bryant D H, Burns M W
Clin Allergy. 1976 Jul;6(4):373-81. doi: 10.1111/j.1365-2222.1976.tb01919.x.
It has been proposed that increased production of IgE, a feature of atopy, is a cause of the non-specific bronchial hyper-reactivity that is characterisitc of asthma. This hypothesis was examined by selecting groups of subjects with asthma or rhinitis and a group of healthy control subjects and studying the relationship between their bronchial histamine reactivity and their atopic status. In none of the groups tested was there a significant association between the degree of bronchial histamine reactivity and either the serum level of total IgE or the number of extracts of aeroallergens giving positive prick test reactions.
有人提出，IgE产生增加是特应性的一个特征，是哮喘所特有的非特异性支气管高反应性的一个原因。通过选择哮喘或鼻炎患者组以及一组健康对照受试者，并研究他们的支气管组胺反应性与特应性状态之间的关系，对这一假设进行了检验。在所有测试组中，支气管组胺反应性程度与总IgE血清水平或引起阳性点刺试验反应的气传变应原提取物数量之间均无显著关联。
