Tomingas R, Pott F, Dehnen W
Cancer Lett. 1976 Mar;1(4):189-95. doi: 10.1016/s0304-3835(75)96635-5.
A study was made to determine whether and to what extent polycyclic aromatic hydrocarbons (PAH) are present in human bronchial carcinoma. Twenty-four carcinomas, obtained from surgical operations and autopsies, were examined. The samples were tested for 12 PAH; these were determined by direct fluorescence analysis on thin-layer plates. Only 4 of the 12 PAH were detected in the cancerous tissue: benzo(a)pyrene, fluoranthene, benzo(ghi)perylene. Beno(a)pyrene was found in all carcinomas. The reasons for increased concentration of the detected PAH in cancerous tissue are discussed with respect to deposition and elimination of inhaled particles as well as the metabolism of these compounds.
开展了一项研究，以确定人类支气管癌中是否存在多环芳烃（PAH）以及其存在的程度。对从手术和尸检中获取的24例癌组织进行了检查。对样本检测了12种多环芳烃；通过在薄层板上进行直接荧光分析来测定这些物质。在癌组织中仅检测到12种多环芳烃中的4种：苯并(a)芘、荧蒽、苯并(ghi)苝。在所有癌组织中均发现了苯并(a)芘。就吸入颗粒物的沉积和清除以及这些化合物的代谢，讨论了癌组织中检测到的多环芳烃浓度升高的原因。
