Gliński W, Jablonska S, Langner A, Obalek S, Haftek M, Proniewska M
Dermatologica. 1976;153(4):218-27. doi: 10.1159/000251060.
Investigations were performed in 6 cases of epidermodysplasia verruciformis and 2 healthy family members. Nonspecific cell-mediated immunity (CMI) was studied by measuring response to phytohemagglutinin (PHA) and concanavalin A (Con A), percentrages of E- and EAC-rosette-forming lymphocytes, bacterial skin tests, and allergic reactions to dinitrochloro-benzene (DNCB). Impairment of CMI was manifested by reduction in the percentage of E rosettes, and lowered response to PHA, and- to a lesser degree- to Con A. The immune response to DNCB sensitization was invariably negative. Impairment of CMI was greater in cases of long duration and with extensive lesions. The cases of similar duration and extent of lesions, which never showed tendency to tumor formation, were not different in CMI in comparison with cases with numerous tumors. Only in cases with very advanced tumors CMI was impaired parallel to the gravity of the patient's general condition.
对6例疣状表皮发育不良患者及2名健康家庭成员进行了研究。通过检测对植物血凝素（PHA）和刀豆球蛋白A（Con A）的反应、E花环和EAC花环形成淋巴细胞的百分比、皮肤细菌试验以及对二硝基氯苯（DNCB）的过敏反应，研究了非特异性细胞介导免疫（CMI）。CMI受损表现为E花环百分比降低，对PHA的反应降低，对Con A的反应降低程度较小。对DNCB致敏的免疫反应始终为阴性。病程长且皮损广泛的病例中CMI受损更严重。病程和皮损范围相似但从未有肿瘤形成倾向的病例，与有大量肿瘤的病例相比，CMI没有差异。只有在肿瘤非常晚期的病例中，CMI才与患者的全身状况严重程度平行受损。
