Maciel R M, Miki S S, Nicolau W, Mendes N F
J Clin Endocrinol Metab. 1976 Mar;42(3):583-7. doi: 10.1210/jcem-42-3-583.
The percentage and absolute numbers of thymos-dependent (T) and thymos-independent (B) peripheral blood lymphocytes, the in vitro response of lymphocytes to phytohemagglutinin (PHA), and the sensitization with 2,4dinitrochlorobenzene (DNCB) was studied in 26 patients with hyperthyroidism due to Graves' disease. The results showed a normal percentage of both T and B cells and increased absoluted numbers of total lymphocytes in patients compared with 30 healthy controls. The in vitro response to PHA was normal in most patients with the exception of 5 of them who showed an impaired response. All patients developed a reaction of delayed hypersensitivity to DNCB. Our study indicated that there is no general abnormality in cell-mediated immunity in Graves' disease.
对26例格雷夫斯病所致甲状腺功能亢进患者的胸腺依赖性（T）和非胸腺依赖性（B）外周血淋巴细胞的百分比及绝对数量、淋巴细胞对植物血凝素（PHA）的体外反应以及对二硝基氯苯（DNCB）的致敏情况进行了研究。结果显示，与30名健康对照者相比，患者的T细胞和B细胞百分比均正常，但淋巴细胞总数的绝对数量增加。除5例反应受损的患者外，大多数患者对PHA的体外反应正常。所有患者对DNCB均出现迟发型超敏反应。我们的研究表明，格雷夫斯病患者的细胞介导免疫一般无异常。
