Arterial endothelial dysfunction related to passive smoking is potentially reversible in healthy young adults.
作者信息
Raitakari O T, Adams M R, McCredie R J, Griffiths K A, Celermajer D S
机构信息
Royal Prince Alfred Hospital, The Heart Research Institute, and University of Sydney, Camperdown NSW, Australia.
出版信息
Ann Intern Med. 1999 Apr 6;130(7):578-81. doi: 10.7326/0003-4819-130-7-199904060-00017.
BACKGROUND
Passive smoking is associated with early arterial damage, but the potential for reversibility of this damage is unknown.
OBJECTIVE
To assess the reversibility of arterial endothelial dysfunction, a key marker of early atherosclerosis.
DESIGN
Cross-sectional study.
SETTING
Academic medical center.
PARTICIPANTS
60 healthy persons 15 to 39 years of age: 20 with no exposure to active or passive smoking, 20 nonsmoking passive smokers (exposure to environmental tobacco smoke for > or = 1 hour per day for > or = 2 years), and 20 former passive smokers.
MEASUREMENTS
Arterial endothelial function measured by noninvasive ultrasonography.
RESULTS
Endothelium-dependent dilatation was significantly better in former passive smokers (5.1% +/- 4.1% [range, -1.2% to 15.6%]) than in current passive smokers (2.3% +/- 2.1% [range, -0.2% to 6.7%]) (P = 0.01), although both groups were significantly impaired compared with nonsmoking controls (8.9% +/- 3.2% [range, 2.1% to 16.7%]) (P < or = 0.01 for both comparisons).
CONCLUSIONS
In healthy young adults, arterial endothelial dysfunction related to passive smoking seems to be partially reversible.
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