Goldstein M F, Grundfast S K, Dunsky E H, Dvorin D J, Lesser R
Department of Medicine, Medical College of Pennsylvania, Hahnemann University School of Medicine, Philadelphia, USA.
Arch Otolaryngol Head Neck Surg. 1999 Mar;125(3):314-9. doi: 10.1001/archotol.125.3.314.
For more than 70 years, the coexistence of asthma and paranasal rhinosinusitis has been noted in the medical literature. Causal relationships have been proposed but not proved. To date, limited evidence exists suggesting that asthma improves after surgical correction of rhinosinusitis.
To determine whether asthma control improved after first-time functional endoscopic sinus surgery (FESS).
A retrospective medical record analysis was performed on 13 patients with chronic bronchial asthma who underwent FESS for medically refractory chronic rhinosinusitis. Patients received comprehensive asthma care before and after FESS (mean, 19.3 and 33.1 months, respectively). Outcomes analyzed included pre- and post-FESS individual and group mean asthma symptom scores, medication use scores, pulmonary function test results, and emergency department visits or hospital admissions for asthma. Patient medical records were obtained from a private allergy-immunology practice affiliated with a medical school. The surgical procedure was performed at a tertiary care teaching hospital by a single ear, nose, and throat surgeon (R.L.).
Following FESS, there was no statistically significant change in group mean asthma symptom scores, asthma medication use scores, pulmonary function test results, and the number of emergency department visits or hospital admissions. Only a few patients demonstrated statistically significant improvement after FESS in asthma symptom scores (1 patient), medication use scores (1 patient), or pulmonary function test results (2 patients).
The data do not support the hypothesis that first-time FESS for medically refractory chronic rhinosinusitis in adult patients with chronic asthma leads to reduced postoperative asthma symptoms or asthma medication use or improved pulmonary function. Based on this limited study, a reexamination of the benefits of sinus surgery to coexisting asthma is in order.
70多年来,医学文献中一直记载着哮喘与鼻旁窦炎并存的情况。虽然有人提出了因果关系,但尚未得到证实。迄今为止,仅有有限的证据表明鼻窦炎手术矫正后哮喘症状有所改善。
确定首次功能性鼻内镜鼻窦手术(FESS)后哮喘控制情况是否得到改善。
对13例因药物治疗无效的慢性鼻窦炎而接受FESS的慢性支气管哮喘患者进行回顾性病历分析。患者在FESS前后均接受了全面的哮喘护理(平均分别为19.3个月和33.1个月)。分析的结果包括FESS前后个体和组的平均哮喘症状评分、药物使用评分、肺功能测试结果以及因哮喘而到急诊科就诊或住院的情况。患者病历来自一所医学院附属的私人过敏免疫诊所。手术由一位耳鼻喉科医生(R.L.)在一家三级护理教学医院进行。
FESS后,组平均哮喘症状评分、哮喘药物使用评分、肺功能测试结果以及急诊科就诊或住院次数均无统计学上的显著变化。只有少数患者在FESS后哮喘症状评分(1例患者)、药物使用评分(1例患者)或肺功能测试结果(2例患者)方面有统计学上的显著改善。
数据不支持以下假设:成年慢性哮喘患者因药物治疗无效的慢性鼻窦炎而首次接受FESS会导致术后哮喘症状减轻、哮喘药物使用减少或肺功能改善。基于这项有限的研究,有必要重新审视鼻窦手术对并存哮喘的益处。