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功能性鼻内镜鼻窦手术治疗慢性鼻窦炎患者中支气管哮喘的生活质量评估及改善模式

Evaluation of Quality of Life and Pattern of Improvement of Bronchial Asthma in Chronic Rhinosinusitis Patients Treated by Functional Endoscopic Sinus Surgery.

作者信息

Sujatha S, Suja V

机构信息

1Department of otorhinolaryngology and head and neck surgery, Government Medical College, Trivandrum, Kerala India.

2Department of dermatology, Government Medical College, Trivandrum, Kerala India.

出版信息

Indian J Otolaryngol Head Neck Surg. 2019 Nov;71(Suppl 3):2176-2181. doi: 10.1007/s12070-019-01586-1. Epub 2019 Jan 22.

Abstract

Chronic inflammatory disorders of the upper airways are extremely prevalent and have a major impact on public health. Sinusitis and bronchial asthma are closely interrelated diseases and sinusitis is known to influence bronchial asthma in its severity and chronicity. Causal relationships have been proposed but not yet proved. The relationship between sinusitis and asthma is academically interesting and has important diagnostic and therapeutic implications. The present study is designed to evaluate the efficacy of functional endoscopic sinus surgery done as treatment for chronic rhinosinusitis on bronchial asthma patients, in terms of quality of life and pattern of improvement. Objectives of the study were to determine whether bronchial asthma and quality of life improved after functional endoscopic sinus surgery. This was an open labelled randomised control trial, done at ENT Department of Medical College, Thiruvananthapuram. Those in Group A underwent functional endoscopic sinus surgery and group B patients were given only medicines as per standard protocol. All of them received asthma treatment depending on asthma attacks and severity and followed up at specific intervals. Quality of life status and pattern of improvement of bronchial asthma among these patients were evaluated. Patients of chronic rhinosinusitis treated by functional endoscopic sinus surgery showed significant improvement in the mean asthma symptom score, asthma medication use score, pulmonary function test results, and quality of life assessment scores. Functional endoscopic sinus surgery could be considered early in the natural course of chronic rhinosinusitis with concomitant bronchial asthma.

摘要

上呼吸道慢性炎症性疾病极为普遍,对公众健康有重大影响。鼻窦炎和支气管哮喘是密切相关的疾病,已知鼻窦炎会在严重程度和慢性化方面影响支气管哮喘。虽然有人提出了因果关系,但尚未得到证实。鼻窦炎与哮喘之间的关系在学术上很有趣,并且具有重要的诊断和治疗意义。本研究旨在评估功能性鼻内镜鼻窦手术作为慢性鼻-鼻窦炎治疗方法对支气管哮喘患者的疗效,包括生活质量和改善模式。该研究的目的是确定功能性鼻内镜鼻窦手术后支气管哮喘和生活质量是否得到改善。这是一项在特里凡得琅医学院耳鼻喉科进行的开放标签随机对照试验。A组患者接受功能性鼻内镜鼻窦手术,B组患者仅按照标准方案给予药物治疗。所有患者均根据哮喘发作情况和严重程度接受哮喘治疗,并在特定时间间隔进行随访。评估了这些患者的生活质量状况和支气管哮喘的改善模式。接受功能性鼻内镜鼻窦手术治疗的慢性鼻-鼻窦炎患者在平均哮喘症状评分、哮喘药物使用评分、肺功能测试结果和生活质量评估评分方面均有显著改善。对于合并支气管哮喘的慢性鼻-鼻窦炎患者,可在其自然病程早期考虑进行功能性鼻内镜鼻窦手术。

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