在仓鼠细胞中表达的人类HLA-A*0201等位基因不是5型腺病毒纤维的高亲和力受体。
The human HLA-A*0201 allele, expressed in hamster cells, is not a high-affinity receptor for adenovirus type 5 fiber.
作者信息
Davison E, Kirby I, Elliott T, Santis G
机构信息
Department of Respiratory Medicine & Allergy, The Guy's, King's College and St. Thomas' Hospitals School of Medicine, Thomas Guy House, Guy's Hospital, London SE1 9RT, United Kingdom.
出版信息
J Virol. 1999 May;73(5):4513-7. doi: 10.1128/JVI.73.5.4513-4517.1999.
Abstract
The coxsackie B virus and adenovirus receptor (CAR) and the major histocompatibility complex (MHC) class I alpha2 domain have been identified as high-affinity cell receptors for adenovirus type 5 (Ad5) fiber. In this study we show that CAR but not MHC class I allele HLA-A*0201 binds to Ad5 with high affinity when expressed on hamster cells. When both receptors are coexpressed on the cell surface of hamster cells, Ad5 fiber bind to a single high-affinity receptor, which is CAR.
摘要
柯萨奇B病毒和腺病毒受体（CAR）以及主要组织相容性复合体（MHC）I类α2结构域已被确定为5型腺病毒（Ad5）纤维的高亲和力细胞受体。在本研究中，我们发现，当在仓鼠细胞上表达时，CAR而非MHC I类等位基因HLA-A*0201能以高亲和力与Ad5结合。当两种受体在仓鼠细胞表面共表达时，Ad5纤维与单一的高亲和力受体结合，该受体即为CAR。
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本文引用的文献
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