Lamers H J, Jamin R H, Zaat J O, Van Eijk J T
Institute for Research in Extramural Medicine (EMGO), Amsterdam, The Netherlands.
Br J Gen Pract. 1998 Dec;48(437):1819-23.
Although there is no evidence that diet shortens acute diarrhoea, doctors tend to give dietary advice.
To test the effects of eating and drinking normally on the duration of acute diarrhoea and on the feeling of well-being.
Randomized single-blinded, controlled trial in urban and semi-urbanized areas. Patients aged 3-70 years suffering with diarrhoea at least three times on the preceding day, lasting no more than five days, were eligible. Two regimes were randomly allocated to practices. In the intervention group, the advice was to eat everything one liked and to drink more. The control group was advised to follow a strict regime of fasting for 24 hours and was subsequently given specified limitations.
No significant differences between the 44 patients in the intervention group and the 27 in the control group were found for the duration of watery diarrhoea (median 14 versus 13 hours), or the total number of evacuations (2 versus 2.5). Among the items concerning well-being, only nausea (51% versus 23%) showed a significant difference.
In this pilot study, the null hypothesis that both treatments will show equal results cannot be confirmed or rejected because of the small number of participants. Despite our efforts, we included fewer patients than expected. This might be due to the data-forms, which were rather complicated and voluminous for both, including doctors and participants.
尽管没有证据表明饮食能缩短急性腹泻病程，但医生往往会给出饮食建议。
测试正常饮食对急性腹泻病程及舒适感的影响。
在城市和半城市化地区进行随机单盲对照试验。年龄在3至70岁、前一天腹泻至少三次且持续不超过五天的患者符合条件。两种方案被随机分配给医疗机构。干预组的建议是想吃什么就吃什么并多喝水。对照组则被建议严格禁食24小时，随后有特定的饮食限制。
干预组的44名患者与对照组的27名患者在水样腹泻病程（中位数分别为14小时和13小时）或排便总次数（分别为2次和2.5次）上未发现显著差异。在有关舒适感的项目中，只有恶心感（51%对23%）存在显著差异。
在这项初步研究中，由于参与者数量较少，两种治疗方法效果相同的零假设无法得到证实或否定。尽管我们做出了努力，但纳入的患者比预期少。这可能是由于数据表格，对医生和参与者来说都相当复杂且篇幅冗长。
