Trouern-Trend J J, Cable R G, Badon S J, Newman B H, Popovsky M A
American Red Cross Blood Services, Connecticut Region, Farmington 06032, USA.
Transfusion. 1999 Mar;39(3):316-20. doi: 10.1046/j.1537-2995.1999.39399219291.x.
Vasovagal reactions occur in a small, but significant number of blood donors. These reactions may decrease return donation and disrupt blood collection activities. The purpose of this study was to define the contributory role of sex, age, weight, blood pressure, and pulse in vasovagal reactions with syncope in blood donors.
A retrospective case-control study involved 1890 blood donors with syncope from three large United States blood centers during 1994 and 1995. Case controls and random population controls were used in a logistic regression analysis to determine the significance of individual variables to syncopal reactions.
Female donors, young donors, first-time donors, low-weight donors, and donors with low predonation blood pressure had higher absolute donation reaction rates than other donors. When each variable was adjusted for other variables by regression analysis, age, weight, and donation status (first-time or repeat donor) were significant (p<0.0001), and sex, predonation blood pressure, and predonation pulse were not. The most important variables, in descending order, were age, weight, and donation status (first-time or repeat donor).
Donation-related vasovagal syncopal reactions are a multifactorial process determined largely by age, weight, and first-time donor status.
血管迷走神经反应在少数但数量可观的献血者中出现。这些反应可能会减少再次献血，并干扰采血活动。本研究的目的是确定性别、年龄、体重、血压和脉搏在献血者血管迷走神经反应伴晕厥中的作用。
一项回顾性病例对照研究纳入了1994年至1995年期间来自美国三个大型血液中心的1890名晕厥献血者。病例对照和随机人群对照用于逻辑回归分析，以确定各个变量对晕厥反应的显著性。
女性献血者、年轻献血者、首次献血者、低体重献血者以及献血前血压低的献血者的绝对献血反应率高于其他献血者。通过回归分析对每个变量进行其他变量调整后，年龄、体重和献血状态（首次或再次献血者）具有显著性（p<0.0001），而性别、献血前血压和献血前脉搏则不具有显著性。按重要性降序排列，最重要的变量是年龄、体重和献血状态（首次或再次献血者）。
与献血相关的血管迷走神经晕厥反应是一个多因素过程，主要由年龄、体重和首次献血者状态决定。
