L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）：一种用于抗体应答调节机制的探针。
L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT): A probe for regulatory mechanisms in antibody responses.
作者信息
Pierce C W, Kapp J A
出版信息
Adv Exp Med Biol. 1978;98:419-28. doi: 10.1007/978-1-4615-8858-0_24.
PMID:102128
Abstract
The synthetic random terpolymer of L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) has been used as a probe to investigate regulatory mechanisms in antibody responses in tissue culture systems. In this brief review, the mechanisms of H-2 linked Ir gene control of antibody responses to GAT and genetic restrictions governing Mphi-immune T cell interactions in antibody responses to GAT are summarized.
摘要
L-谷氨酸60-L-丙氨酸30-L-酪氨酸10的合成无规三元共聚物（GAT）已被用作一种探针，以研究组织培养系统中抗体应答的调节机制。在这篇简短的综述中，总结了H-2连锁Ir基因对GAT抗体应答的控制机制以及在GAT抗体应答中巨噬细胞-免疫T细胞相互作用的遗传限制。
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L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT): A probe for regulatory mechanisms in antibody responses.L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）：一种用于抗体应答调节机制的探针。
Adv Exp Med Biol. 1978;98:419-28. doi: 10.1007/978-1-4615-8858-0_24.
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The involvement of suppressor T cells in Ir gene regulation of secondary antibody responses of primed (responder X nonresponder)F1 mice to macrophage-bound L-glutamic acid60-L-alanine30-L-tyrosine.抑制性T细胞参与致敏（反应者×无反应者）F1小鼠对巨噬细胞结合的L-谷氨酸60-L-丙氨酸30-L-酪氨酸二次抗体反应的Ir基因调控。
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J Exp Med. 1978 Apr 1;147(4):997-1006. doi: 10.1084/jem.147.4.997.
4
H-2-linked Ir gene control of T cell proliferative responses to the synthetic terpolymer L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT). I. Requirements for T cell activation in responder and nonresponder mice.H-2连锁Ir基因对T细胞针对合成三聚物L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）增殖反应的控制。I. 反应性和无反应性小鼠中T细胞激活的要求。
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Shared idiotypic determinants on antibodies and T-cell-derived suppressor factor specific for the random terpolymer L-glutamic acid60-L-alanine30-L-tyrosine10.针对随机三元共聚物L-谷氨酸60-L-丙氨酸30-L-酪氨酸10的抗体和T细胞衍生抑制因子上的共享独特型决定簇。
J Exp Med. 1979 Mar 1;149(3):613-22. doi: 10.1084/jem.149.3.613.
6
Suppressor T-cell activity in responder X nonresponder (C57BL/10 X DBA/1)F1 spleen cells responsive to L-glutamic acid60-L-alanine30-L-tyrosine10.对L-谷氨酸60-L-丙氨酸30-L-酪氨酸10有反应的反应者X无反应者（C57BL/10×DBA/1）F1脾细胞中的抑制性T细胞活性
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8
Antigen-specific suppressor T-cell activity in genetically restricted immune spleen cells.基因受限免疫脾细胞中的抗原特异性抑制性T细胞活性。
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Secondary antibody responses in vitro to L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) by (responder X nonresponder)F1 spleen cells stimulated by parental GAT-macrophages.亲本GAT-巨噬细胞刺激的（反应者X无反应者）F1脾细胞对L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）的体外二次抗体反应。
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10
Suppression of antibody and T cell proliferative responses to L-glutamic acid60-L-alanine30-L-tyrosine10 by a specific monoclonal T cell factor.一种特异性单克隆T细胞因子对L-谷氨酸60-L-丙氨酸30-L-酪氨酸10抗体及T细胞增殖反应的抑制作用
J Exp Med. 1980 Jul 1;152(1):235-40. doi: 10.1084/jem.152.1.235.
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