Greer I A
Department of Obstetrics and Gynaecology, University of Glasgow, Glasgow Royal Infirmary, UK.
Lancet. 1999 Apr 10;353(9160):1258-65. doi: 10.1016/S0140-6736(98)10265-9.
Pulmonary thromboembolism is the main cause of maternal death in the UK and current trends show an increase. Deep-vein thrombosis underlies this disorder. Important issues include pathophysiology, diagnosis, and management of thrombosis in pregnancy, especially the use of anticoagulants. Congenital and acquired thrombophilias contribute to the pathophysiological processes that underlie miscarriage, intrauterine growth restriction, and pre-eclampsia, and raises new possibilities for intervention. The high prevalence of thrombophilic defects in the population, the association of defects with maternal and fetal disorders, and special considerations for management make it essential for obstetricians to understand this area.
肺血栓栓塞是英国孕产妇死亡的主要原因，且目前的趋势显示其有上升态势。深静脉血栓形成是这一病症的基础。重要问题包括妊娠期血栓形成的病理生理学、诊断及管理，尤其是抗凝剂的使用。先天性和获得性血栓形成倾向参与了流产、胎儿生长受限及子痫前期的病理生理过程，并为干预带来了新的可能性。人群中血栓形成倾向缺陷的高患病率、缺陷与母婴疾病的关联以及管理方面的特殊考量，使得产科医生了解这一领域至关重要。
