Ugolini S, Mondor I, Sattentau Q J
Centre d'Immunologie de Marseille-Luminy, 163 Avenue de Luminy, Case 906, 13288 Marseille Cedex 9, France.
Trends Microbiol. 1999 Apr;7(4):144-9. doi: 10.1016/s0966-842x(99)01474-2.
HIV-1 attachment to host cells is generally considered to take place via high-affinity binding between CD4 and gp120. However, the binding of virion-associated gp120 to cellular CD4 is often weak, and most cell types that are permissive for HIV-1 infection express little CD4. Thus, other interactions between the virion and the cell surface could dominate the attachment process.
一般认为，HIV-1与宿主细胞的附着是通过CD4与gp120之间的高亲和力结合发生的。然而，病毒体相关的gp120与细胞CD4的结合往往较弱，并且大多数允许HIV-1感染的细胞类型表达的CD4很少。因此，病毒体与细胞表面之间的其他相互作用可能在附着过程中起主导作用。
