病毒对细胞因子调节通路的拦截
Virus interception of cytokine-regulated pathways.
作者信息
Kalvakolanu D V
机构信息
Greenebaum Cancer Center, Dept of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
出版信息
Trends Microbiol. 1999 Apr;7(4):166-71. doi: 10.1016/s0966-842x(99)01476-6.
Abstract
Cytokines regulate host antiviral, immune and antitumor responses. Viruses combat the host-imposed inhibitory pathways to survive and spread the infection. Some viruses have evolved molecules that override apoptotic programs to promote cell survival until virus assembly is complete, persistence is established or cellular transformation occurs.
摘要
细胞因子调节宿主的抗病毒、免疫和抗肿瘤反应。病毒对抗宿主施加的抑制途径以存活并传播感染。一些病毒已经进化出分子来超越凋亡程序，以促进细胞存活，直到病毒组装完成、建立持续性感染或发生细胞转化。
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