人牙髓和根尖周病变中白细胞介素-6的检测

Detection of interleukin-6 in human dental pulp and periapical lesions.

作者信息

Barkhordar R A, Hayashi C, Hussain M Z

机构信息

Department of Restorative Dentistry, School of Dentistry, University of California at San Francisco 94143-0758, USA.

出版信息

Endod Dent Traumatol. 1999 Feb;15(1):26-7. doi: 10.1111/j.1600-9657.1999.tb00744.x.

DOI:10.1111/j.1600-9657.1999.tb00744.x

PMID:10219150

Abstract

Pulpal and periapical diseases are characterized by inflammation. The cytokine IL-6 is a major mediator of the host response to tissue injury and infection. This study examined the level of interleukin-6 (IL-6) in six inflamed human pulps and six human periapical lesions of endodontic origin using ELISA. Pulp samples from eight clinically impacted teeth were used as controls. The periapical samples exhibited significant levels of IL-6 (mean = 78.1 +/- 9 pg/mg protein) as did inflamed pulpal tissues mean = 36 +/- 3.9 pg/mg protein) compared to healthy pulp mean = 0.01 +/- 0.02 pg/mg protein). These data indicated that IL-6 was produced and released locally in the inflamed pulpal and periapical lesions.

摘要

牙髓病和根尖周病的特征是炎症。细胞因子白细胞介素-6（IL-6）是宿主对组织损伤和感染反应的主要介质。本研究使用酶联免疫吸附测定法（ELISA）检测了6例炎症牙髓和6例牙髓源性根尖周病变中的白细胞介素-6（IL-6）水平。来自8颗临床阻生牙的牙髓样本用作对照。与健康牙髓（平均值 = 0.01 ± 0.02 pg/mg蛋白质）相比，根尖周样本显示出显著水平的IL-6（平均值 = 78.1 ± 9 pg/mg蛋白质），炎症牙髓组织也是如此（平均值 = 36 ± 3.9 pg/mg蛋白质）。这些数据表明，IL-6在炎症牙髓和根尖周病变中局部产生和释放。