Dunbar M E, Wysolmerski J J
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8020, USA.
J Mammary Gland Biol Neoplasia. 1999 Jan;4(1):21-34. doi: 10.1023/a:1018700502518.
Parathyroid hormone-related protein (PTHrP) was originally identified as the tumor factor responsible for a clinical syndrome known as humoral hypercalcemia of malignancy. It is now appreciated that PTHrP3 is a developmental regulatory molecule expressed during the formation of a wide variety of organs. Recently, our laboratory has demonstrated that PTHrP is necessary for mammary gland development. Our studies have suggested that this molecule participates in the regulation of epithelial-mesenchymal interactions during embryonic mammary development and perhaps also during adolescent ductal morphogenesis. In addition, it has been suggested that PTHrP plays a critical role in the establishment of bone metastases in breast cancer. In this article, we will discuss the current knowledge of the mechanisms underlying PTHrPs actions during normal mammary development and in breast cancer.
甲状旁腺激素相关蛋白（PTHrP）最初被鉴定为导致一种名为恶性肿瘤体液性高钙血症临床综合征的肿瘤因子。现在人们认识到，PTHrP3是一种在多种器官形成过程中表达的发育调节分子。最近，我们实验室已证明PTHrP对乳腺发育是必需的。我们的研究表明，该分子在胚胎期乳腺发育过程中，或许也在青春期导管形态发生过程中，参与上皮-间充质相互作用的调节。此外，有人提出PTHrP在乳腺癌骨转移的形成中起关键作用。在本文中，我们将讨论关于PTHrP在正常乳腺发育及乳腺癌过程中作用机制的当前知识。
