Raulf-Heimsoth M, Baur X
Berufsgenossenschaftliches Forschungsinstitut für Arbeitsmedizin (BGFA), Ruhr-Universität Bochum.
Pneumologie. 1999 Mar;53(3):143-9.
During recent years in industrial countries, isocyanates have been one of the main causes of occupational asthma. The mechanisms of isocyanate-induced disorders are still unknown but recent evidence suggests immunological reactions, including cell-mediated immune responses. Immune responses to isocyanates may result in different illnesses, some of which represent cell- and/or antibody-mediated entities. In addition, irritative, toxic, and mutagenic effects may occur. This review summarizes current knowledge of the pathomechanisms, including immunological and nonimmunological (genotoxic and mutagenic) aspects of isocyanate disorders.
近年来，在工业化国家，异氰酸酯一直是职业性哮喘的主要病因之一。异氰酸酯诱发疾病的机制尚不清楚，但最近的证据表明存在免疫反应，包括细胞介导的免疫应答。对异氰酸酯的免疫反应可能导致不同疾病，其中一些代表细胞和/或抗体介导的病症。此外，还可能出现刺激、毒性和诱变作用。本综述总结了目前关于发病机制的知识，包括异氰酸酯疾病的免疫和非免疫（遗传毒性和诱变）方面。
