Mullins J M, Penafiel L M, Juutilainen J, Litovitz T A
Department of Biology, Catholic University of America, Washington, DC 20064, USA.
Bioelectrochem Bioenerg. 1999 Feb;48(1):193-9. doi: 10.1016/s0302-4598(98)00229-3.
Alteration of ODC activity in animals or cultured cells exposed to extremely low frequency electromagnetic fields, or to modulated microwave fields, has been documented by several laboratories. However, an evaluation of the dose-response relationship in these experiments has not been done. We examined ODC activity in L929 fibroblasts exposed for 4 h to 60 Hz magnetic fields of different amplitudes. Our results show a clear threshold response which could be fitted to a sigmoidal function, with the 50% point occurring at approximately 5 microT. This sigmoidal response is characteristic of biological responses which are governed by ligand-receptor binding, and has been previously observed in the incidence of magnetic-field induced morphological abnormalities in chick embryos. The implications of this study are discussed in terms of environmental exposures to EM fields.
几个实验室已记录了暴露于极低频电磁场或调制微波场的动物或培养细胞中鸟氨酸脱羧酶（ODC）活性的改变。然而，尚未对这些实验中的剂量-反应关系进行评估。我们检测了暴露于不同振幅60赫兹磁场4小时的L929成纤维细胞中的ODC活性。我们的结果显示出明显的阈值反应，该反应可以拟合为S形函数，50%的点出现在约5微特斯拉处。这种S形反应是由配体-受体结合控制的生物反应的特征，并且先前已在磁场诱导的鸡胚形态异常发生率中观察到。本文从环境暴露于电磁场的角度讨论了该研究的意义。
