Davis P, Russell A S, Percy J S
J Rheumatol. 1976 Dec;3(4):375-9.
Antibodies to ultraviolet light denatured DNA (UV DNA) have been measured in patients with systemic lupus erythematosus (SLE) and normal subjects, using a millipore filter radioimmunoassay. High levels of UV DNA binding were only found in patients with SLE. The presence of UV DNA antibodies correlated well with the presence of native DNA antibodies, although immunodiffusion studies and inhibition techniques showed these antibodies to be immunologically distinct in many cases. Forty-one per cent of the SLE patients had had photosensitivity at some stage of their disease, but there was a poor correlation between this symptom and the presence of UV DNA antibodies. Although UV DNA is known to be a potent immunogen, none of the results from this study suggests that antibodies to UV DNA are more than another example of the broad spectrum of antinuclear antibodies seen in SLE.
采用微孔滤膜放射免疫分析法，检测了系统性红斑狼疮（SLE）患者和正常受试者体内针对紫外线变性DNA（UV DNA）的抗体。仅在SLE患者中发现高水平的UV DNA结合。UV DNA抗体的存在与天然DNA抗体的存在密切相关，尽管免疫扩散研究和抑制技术表明，在许多情况下这些抗体在免疫学上是不同的。41%的SLE患者在疾病的某个阶段有光敏性，但该症状与UV DNA抗体的存在之间相关性较差。虽然已知UV DNA是一种有效的免疫原，但这项研究的结果均未表明针对UV DNA的抗体不仅仅是SLE中所见的广谱抗核抗体的另一个例子。
