Hornabrook R W, Nagurney J T
Brain. 1976 Dec;99(4):659-72. doi: 10.1093/brain/99.4.659.
The clinical features of 175 cases of essential tremor are related. This disorder is prevalent among a population of the Eastern Highlands of Papua New Guinea. It affects predominantly women in middle and old age; only 27 per cent of the cases were males. The disorder is slowly progressive and significant disability appears in elderly women when the trunk muscles are involved. Epidemiological studies have shown that the presence of tremor can be correlated with linguistic distinctions between high and low prevalence populations. Although only 30 patients reported a first degree relative with tremor, the syndrome would seem to stem from a genetic predisposition. In a number of patients essential tremor appeared to be associated with Parkinson's disease.
175例特发性震颤的临床特征具有相关性。这种疾病在巴布亚新几内亚东部高地人群中很普遍。它主要影响中老年女性；仅27%的病例为男性。该疾病进展缓慢，当老年女性的躯干肌肉受累时会出现明显残疾。流行病学研究表明，震颤的存在与高患病率和低患病率人群之间的语言差异相关。尽管只有30名患者报告有震颤的一级亲属，但该综合征似乎源于遗传易感性。在一些患者中，特发性震颤似乎与帕金森病有关。
