Tarkowski S, Wisniewska-Knypl J M, Klimczak J, Dramiński W, Wróblewska K
J Hyg Epidemiol Microbiol Immunol. 1980;24(3):253-61.
In order to assess the process of oxidation and conjugation involved in biotransformation of vinyl chloride (VC), rats were exposed to 50, 200, 500, 1000 and 20,000 ppm inhaled VC. The rate of urinary excretion of thiodiglycollic acid (TDGA) after exposure to each investigated concentration of VC depends on the activity of microsomal monooxygenase. In general, higher levels of TDGA in urine were reflected by a more significant depression of non-protein sulfhydryl content in the liver of rats, whereas no changes were observed in those with inhibited activity of microsomal monooxygenase and depressed urinary levels of TDGA. The significance of alcohol dehydrogenase in the metabolism of low concentrations of VC has not been confirmed. Metabolism of VC in the range of 50--2 000 ppm is mediated by microsomal monooxygenase followed by conjugation with thiols.
为了评估氯乙烯（VC）生物转化过程中的氧化和结合过程，将大鼠暴露于50、200、500、1000和20000 ppm的吸入VC中。暴露于每种研究浓度的VC后，硫代二乙醇酸（TDGA）的尿排泄率取决于微粒体单加氧酶的活性。一般来说，大鼠肝脏中非蛋白巯基含量的更显著降低反映在尿中TDGA水平较高，而微粒体单加氧酶活性受到抑制且尿中TDGA水平降低的大鼠未观察到变化。尚未证实乙醇脱氢酶在低浓度VC代谢中的重要性。50-2000 ppm范围内的VC代谢由微粒体单加氧酶介导，随后与硫醇结合。
