Gaultier M, Conso F, Rudler M, Leclerc J P, Mellerio F
Eur J Toxicol Environ Hyg. 1976 Nov-Dec;9(6):373-9.
During last 7 years, 13 cases of acute ethylene glycol poisoning have been observed with 4 fatal outbreaks. All cases--except one--were accidental. Six patients had drunk a mixture of antifreeze in water as they were lost in a desert. A patient who had taken 970 ml of ethylene glycol survived. In one case, death was due to irreversible brain damage; two other fatalities occurred from cardiorespiratory distress. CNS involvement was noticed in 8 cases and acute renal failure-constantly controlled-occurred in 9 patients. Post mortem examination has shown bi-refringent calcium oxalate crystals in both kidney and brain. Specific treatment with ethanol has been performed in 3 cases with ingestion of large amounts of toxic who were seen before definitive renal lesions have occurred. Emphasis is placed in symptomatic treatment including gastric lavage, extrarenal epuration and conservative management.
在过去7年里，共观察到13例急性乙二醇中毒病例，其中有4例致命。除1例外，所有病例均为意外中毒。6名患者在沙漠中迷路时饮用了防冻液与水的混合物。一名摄入970毫升乙二醇的患者存活了下来。有1例死亡是由于不可逆的脑损伤；另外2例死于心肺功能衰竭。8例出现中枢神经系统受累，9例出现急性肾衰竭（一直处于可控状态）。尸检显示肾脏和大脑中均有双折射草酸钙晶体。3例在出现明确的肾脏损害之前就诊的大量摄入毒物的患者接受了乙醇特效治疗。重点在于对症治疗，包括洗胃、肾外净化和保守治疗。
