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猴子实验性埃博拉病毒感染的病理学

The pathology of experimental Ebola virus infection in monkeys.

作者信息

Baskerville A, Bowen E T, Platt G S, McArdell L B, Simpson D I

出版信息

J Pathol. 1978 Jul;125(3):131-8. doi: 10.1002/path.1711250303.

DOI:10.1002/path.1711250303
PMID:102747
Abstract

Six rhesus and two vervet monkeys were infected intraperitoneally with Ebola virus. They developed an acute haemorrhagic fever with skin rash 4 days later and died 6--12 days after infection. Histopathological lesions of acute necrosis were present in the liver, spleen, lymph nodes, lungs and testes. The presence of fibrin thrombi in several organs was suggestive of the occurrence of disseminated intravascular coagulation during the infection.

摘要

六只恒河猴和两只绿猴经腹腔感染埃博拉病毒。4天后,它们出现了伴有皮疹的急性出血热,并在感染后6至12天死亡。肝脏、脾脏、淋巴结、肺和睾丸出现急性坏死的组织病理学病变。多个器官中存在纤维蛋白血栓,提示感染期间发生了弥散性血管内凝血。

相似文献

1
The pathology of experimental Ebola virus infection in monkeys.猴子实验性埃博拉病毒感染的病理学
J Pathol. 1978 Jul;125(3):131-8. doi: 10.1002/path.1711250303.
2
Ebola haemorrhagic fever: experimental infection of monkeys.埃博拉出血热:猴子的实验性感染
Trans R Soc Trop Med Hyg. 1978;72(2):188-91. doi: 10.1016/0035-9203(78)90058-5.
3
Ebola virus: a comparison, at ultrastructural level, of the behaviour of the Sudan and Zaire strains in monkeys.埃博拉病毒:在超微结构水平上对苏丹株和扎伊尔株在猴子体内行为的比较。
Br J Exp Pathol. 1978 Dec;59(6):584-93.
4
Pathology of Bolivian hemorrhagic fever in the rhesus monkey.恒河猴感染玻利维亚出血热的病理学
Am J Pathol. 1973 Nov;73(2):477-94.
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Ultrastructural pathology of experimental Ebola haemorrhagic fever virus infection.实验性埃博拉出血热病毒感染的超微结构病理学
J Pathol. 1985 Nov;147(3):199-209. doi: 10.1002/path.1711470308.
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Ebola haemorrhagic fever in Sudan, 1976. Report of a WHO/International Study Team.1976年苏丹的埃博拉出血热。世界卫生组织/国际研究小组报告
Bull World Health Organ. 1978;56(2):247-70.
7
Pathology of chronic Bolivian hemorrhagic fever in the rhesus monkey.恒河猴慢性玻利维亚出血热的病理学
Am J Pathol. 1976 Aug;84(2):211-24.
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Model for disseminated intravascular coagulation: bacterial sepsis in rhesus monkeys.
J Lab Clin Med. 1978 Aug;92(2):239-51.
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Pathology of 12 fatal cases of Argentine hemorrhagic fever.12例阿根廷出血热死亡病例的病理学研究
Am J Trop Med Hyg. 1973 Mar;22(2):229-36.
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Combined simian hemorrhagic fever and Ebola virus infection in cynomolgus monkeys.食蟹猴的猿猴出血热与埃博拉病毒合并感染
Lab Anim Sci. 1992 Apr;42(2):152-7.

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