Ellis D S, Bowen E T, Simpson D I, Stamford S
Br J Exp Pathol. 1978 Dec;59(6):584-93.
Histopathological and electron microscopical examination of human liver specimens collected during the Ebola haemorrhagic fever outbreaks in Zaire and Sudan indicated that Zairean strains of the virus produced more extensive lesions. Experimental infection of rhesus monkeys wiht Zairean and Sudanese strains of Ebola virus produced similar changes to those found in man. In Zairean strain infections large numbers of virus particles were found in the liver, lung and spleen accompanied by extensive necrosis in the spleen. In Sudan strain infections particles were found only in the liver and in greatly reduced numbers. The main distinction lay in the high proportion of aberrant particles found with the Sudanese strain. The possibility of these being defective particles is discussed.
对在扎伊尔和苏丹埃博拉出血热疫情期间采集的人类肝脏标本进行的组织病理学和电子显微镜检查表明，扎伊尔的病毒株造成的损害更为广泛。用扎伊尔和苏丹埃博拉病毒株对恒河猴进行实验性感染，产生了与在人类身上发现的类似变化。在扎伊尔病毒株感染中，在肝脏、肺和脾脏中发现了大量病毒颗粒，同时脾脏出现广泛坏死。在苏丹病毒株感染中，仅在肝脏中发现了颗粒，且数量大幅减少。主要区别在于，苏丹病毒株中发现的异常颗粒比例很高。文中讨论了这些颗粒可能是缺陷颗粒的可能性。
