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埃博拉出血热:猴子的实验性感染

Ebola haemorrhagic fever: experimental infection of monkeys.

作者信息

Bowen E T, Platt G S, Simpson D I, McArdell L B, Raymond R T

出版信息

Trans R Soc Trop Med Hyg. 1978;72(2):188-91. doi: 10.1016/0035-9203(78)90058-5.

DOI:10.1016/0035-9203(78)90058-5
PMID:418537
Abstract

Experimental infection of rhesus and vervet monkeys with Ebola virus produced a uniformly fatal illness. The course of the disease resembled that found in man with weight loss, anorexia, fever, haemorrhages and skin rash being frequently seen. Viraemia was obvious within two days of infection and persisted until death which occurred between days five and eight. Virus was found in high concentrations in several organs but particularly in the liver, spleen, and lungs.

摘要

用埃博拉病毒对恒河猴和绿猴进行实验性感染,引发了一种无一例外会致命的疾病。该病病程与人类患者相似,常出现体重减轻、厌食、发热、出血和皮疹等症状。感染后两天内即出现明显病毒血症,并持续至死亡,死亡发生在第5至8天之间。在多个器官中发现高浓度病毒,尤其是肝脏、脾脏和肺部。

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Ebola haemorrhagic fever: experimental infection of monkeys.埃博拉出血热:猴子的实验性感染
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