Daum R S, Scheifele D W, Syriopoulou V P, Averill D, Smith A L
J Pediatr. 1978 Dec;93(6):927-30. doi: 10.1016/s0022-3476(78)81213-x.
We determined the frequency of ventricular involvement during Hemophilus influenzae type b meningitis in ten bacteremic infant rhesus monkeys. Meningitis was defined as cerebrospinal fluid obtained from the lumbar subarachnoid space or cisterna magna containing bacteria and ten or more leukocytes per mm3. HIB were cultured from 22 of 22 ventricular CSF samples. In 17 of 18 comparisons of bacterial density in ventricular and cisternal CSF, the values were within one log10: similarly, 5 of 8 quantitative ventricular-lumbar comparisons were within one log10. This concordance was present at bacterial densities of 2 x 10(1) to 1 x 10(9) CFU/ml. When discordance was present, the ventricular CSF contained more bacteria. In 15 of 20 comparisons of leukocyte density in ventricular and cisternal CSF, the ventricular pleocytosis was lower (mean ventricular/cisternal ratio 0.08). We conclude that infection of the lateral cerebral ventricle is a uniform feature of HIB meningitis in infant monkeys, but the cellular inflammatory component is less.
我们测定了10只患菌血症的幼年恒河猴在感染b型流感嗜血杆菌脑膜炎期间脑室受累的频率。脑膜炎的定义为从腰蛛网膜下腔或枕大池获取的脑脊液中含有细菌且每立方毫米有10个或更多白细胞。在22份脑室脑脊液样本中，有22份培养出了b型流感嗜血杆菌。在18次对脑室和脑池脑脊液中细菌密度的比较中，有17次两者的值相差在1个对数10以内；同样，在8次脑室与腰椎脑脊液的定量比较中，有5次相差在1个对数10以内。这种一致性在细菌密度为2×10¹至1×10⁹CFU/ml时均存在。当出现不一致时，脑室脑脊液中的细菌更多。在20次对脑室和脑池脑脊液中白细胞密度的比较中，有15次脑室的细胞增多症较轻（脑室与脑池的平均比值为0.08）。我们得出结论，在幼年猴子中，侧脑室感染是b型流感嗜血杆菌脑膜炎的一个一致特征，但细胞炎症成分较少。
