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[睾酮及其酯类肌肉注射后剂量反应关系的定量评估]

[Quantitative evaluation of the dose-response relationship after intramuscular administration of testosterone and its esters].

作者信息

Fedorov V K, Shashkina L F, Liberman M D

出版信息

Probl Endokrinol (Mosk). 1976 Jul-Aug;22(4):92-7.

PMID:1028048
Abstract

Experiments were conducted on rats. A study was made of the reaction of target organs to the intramuscular injection of androgenic preparations--testosterone and its esters (acetate, propionate, phenylpropionate, isocapronate, enantate and caprinate) comparison with anabolic methylandrostendiol. An equation is presented for mathematical description of the dependence of the androgenic effect on the dose of the praparations injected, used in a wide range of doses. The equation coefficients proved to have a definite physiological sense.

摘要

在大鼠身上进行了实验。研究了靶器官对肌肉注射雄激素制剂(睾酮及其酯类,如醋酸酯、丙酸酯、苯丙酸酯、异己酸酯、庚酸酯和癸酸酯)的反应,并与同化性甲基雄烯二醇进行了比较。给出了一个方程,用于数学描述雄激素作用与所注射制剂剂量之间的依赖关系,该方程在很宽的剂量范围内都适用。事实证明,方程系数具有一定的生理意义。

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