Zaks A S, Bykova A A, Ponomareva S I
Farmakol Toksikol. 1976 Nov-Dec;39(6):695-8.
Experiments conducted on rabbits demonstrated formation of antiserotonin antibodies in response to introduction to the animals of a serotonin-proteinic conjugate. The effect of antibodies on the development of a serotonin- and dextran-induced inflammation in rats and on the serotonin level in cells of slices of their organs, as well as in the blood thrombocytes was studied. The antibodies were found to produce an antiphlogistic effect in regard to exogenous (serotonin-induced) and endogenous (dextran-induced inflammation) serotonin. Histochemical investigations showed the antibodies to exert a neutralizing action on intracellular serotonin.
在兔子身上进行的实验表明，将血清素 - 蛋白质共轭物引入动物体内会引发抗血清素抗体的形成。研究了这些抗体对大鼠血清素和右旋糖酐诱导的炎症发展的影响，以及对其器官切片细胞和血液血小板中血清素水平的影响。结果发现，这些抗体对外源性（血清素诱导）和内源性（右旋糖酐诱导的炎症）血清素均具有抗炎作用。组织化学研究表明，这些抗体对细胞内血清素具有中和作用。
