Storz G, Imlay J A
Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Curr Opin Microbiol. 1999 Apr;2(2):188-94. doi: 10.1016/s1369-5274(99)80033-2.
Much has been learnt about oxidative stress from studies of Escherichia coli. Key regulators of the adaptive responses in this organism are the SoxRS and OxyR transcription factors, which induce the expression of antioxidant activities in response to O2*- and H2O2 stress, respectively. Recently, a variety of biochemical assays together with the characterization of strains carrying mutations affecting the antioxidant activities and the regulators have given general insights into the sources of oxidative stress, the damage caused by oxidative stress, defenses against the oxidative stress, and the mechanisms by which the stress is perceived. These studies have also shown that the oxidative stress responses are intimately coupled to other regulatory networks in the cell.
通过对大肠杆菌的研究，我们对氧化应激有了很多了解。该生物体适应性反应的关键调节因子是SoxRS和OxyR转录因子，它们分别在应对超氧阴离子和过氧化氢应激时诱导抗氧化活性的表达。最近，各种生化分析以及对携带影响抗氧化活性和调节因子突变的菌株的表征，使我们对氧化应激的来源、氧化应激造成的损伤、对氧化应激的防御以及应激感知机制有了全面的认识。这些研究还表明，氧化应激反应与细胞中的其他调节网络密切相关。
