母婴获得性GBV-C/HGV感染的结局。
Outcome of mother to infant acquired GBV-C/HGV infection.
作者信息
Zuin G, Saccani B, Di Giacomo S, Tanzi E, Zanetti A R, Principi N
机构信息
Fourth Paediatric Department, Università di Milano, Istituto di Scienze Biomediche Sacco, Italy.
出版信息
Arch Dis Child Fetal Neonatal Ed. 1999 Jan;80(1):F72-3. doi: 10.1136/fn.80.1.f72.
Twelve children born to hepatitis C virus antibody GBV-C/HGV RNA positive mothers who acquired GBV-C/HGV infection by the vertical or perinatal route were studied. Most (91%) were persistently GBV-C/HGV RNA positive up to 12 months of age. Four out of six cases who acquired GBV-C/HGV alone had normal alanine amino transferase activities. Long lasting evidence of hepatocellular injury was detected only in children with GBV-C/HGV and hepatitis C virus and HIV coinfection.
对12名出生于丙型肝炎病毒抗体、GBV-C/HGV RNA呈阳性母亲的儿童进行了研究，这些儿童通过垂直或围产期途径感染了GBV-C/HGV。大多数（91%）在12个月龄时GBV-C/HGV RNA持续呈阳性。仅感染GBV-C/HGV的6例病例中有4例丙氨酸转氨酶活性正常。仅在同时感染GBV-C/HGV、丙型肝炎病毒和HIV的儿童中检测到肝细胞损伤的长期证据。
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