Lockhart S R, Joly S, Vargas K, Swails-Wenger J, Enger L, Soll D R
Department of Biological Sciences, University of Iowa, Iowa City 52242-1324, USA.
J Dent Res. 1999 Apr;78(4):857-68. doi: 10.1177/00220345990780040601.
Candida colonization of the oral cavity increases in the elderly. A major predisposing condition is denture use, which also increases in the elderly. To test whether the increase in colonization is age-related in a fashion independent of denture use, we analyzed the frequency (incidence) of carriage, the intensity of carriage, the multiplicity of species, and the genetic relatedness of strains in the oral cavities of 93 test subjects separated into the three age groups: 60 to 69 yr, 70 to 79 yr, and > or = 80 yr. Each age group was further subdivided into subjects with and without dentures, and into males and females. The results demonstrate that the frequency of carriage, the intensity of carriage, and multispecies carriage all increase as a function of age and differ according to gender, in both cases independent of denture use, suggesting that the natural suppression of yeast carriage in the oral cavity breaks down in the elderly. In addition, it is demonstrated that Candida glabrata colonizes the oral cavities of elderly individuals without dentures only after 80 yr of age, suggesting that there are age-related compromising conditions other than denture use in this most elderly age group.
老年人口腔念珠菌定植增加。一个主要的易感因素是佩戴假牙，而佩戴假牙在老年人中也更为常见。为了测试定植增加是否以与佩戴假牙无关的方式与年龄相关，我们分析了93名受试对象口腔中念珠菌的携带频率（发生率）、携带强度、菌种多样性以及菌株的遗传相关性。这些受试对象被分为三个年龄组：60至69岁、70至79岁以及≥80岁。每个年龄组又进一步细分为佩戴假牙和未佩戴假牙的受试者，以及男性和女性。结果表明，携带频率、携带强度和多种念珠菌携带均随年龄增长而增加，且因性别而异，这两种情况均与佩戴假牙无关，这表明口腔中酵母菌携带的自然抑制在老年人中失效。此外，研究表明光滑念珠菌仅在80岁以后才会定植于未佩戴假牙的老年个体口腔中，这表明在这个最年长的年龄组中，除了佩戴假牙外，还存在与年龄相关的影响因素导致口腔念珠菌定植增加。
