Lyon Juliana Pereira, da Costa Sérgio Carvalho, Totti Valéria Maria Gomes, Munhoz Maira Forestti Vieira, de Resende Maria Aparecida
Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Can J Microbiol. 2006 May;52(5):462-7. doi: 10.1139/w05-148.
Candida species are a normal commensal present in a large percentage of healthy individuals. Denture wearers are predisposed to the development of candidosis and to the presence of Candida spp. The presence of the yeast, even in healthy subjects, should be considered more carefully. We investigated the prevalence of Candida spp. in 112 denture wearers and 103 individuals with natural teeth, patients from the clinic of total prosthesis of the Dental School of the Federal University of Minas Gerais, Brazil, and from the School of Pharmacy and Dentistry of Alfenas, Brazil. Factors like gender, age over 60 years, low education, and xerostomia were directly associated with the presence of Candida yeasts at a significance level of 5% (p > 0.05). However, the major predisposing factor for the carrier state was wearing dentures (p = 0.001). Candida isolates were identified using morphological and biochemical profiles. Seventy-one isolates were identified as C. albicans (65.1%), 15 as C. glabrata (13.7%), 8 as C. parapsilosis (7.3%), 3 as C. krusei (2.7%), and 12 as C. tropicalis (11.0%). Susceptibility testing to fluconazole and itraconazole was also performed with the strains obtained. Both drugs showed a strong inhibition against most oral isolates.
念珠菌属是很大比例的健康个体中存在的正常共生菌。佩戴假牙者易患念珠菌病且易携带念珠菌属。即使在健康受试者中，酵母菌的存在也应更仔细地考虑。我们调查了巴西米纳斯吉拉斯联邦大学牙科学院全口义齿诊所以及巴西阿尔费纳斯药学院和牙科学院的112名假牙佩戴者和103名天然牙患者中念珠菌属的患病率。性别、60岁以上年龄、低教育水平和口干等因素与念珠菌酵母菌的存在直接相关，显著性水平为5%（p>0.05）。然而，携带状态的主要诱发因素是佩戴假牙（p = 0.001）。使用形态学和生化特征鉴定念珠菌分离株。71株分离株被鉴定为白色念珠菌（65.1%），15株为光滑念珠菌（13.7%），8株为近平滑念珠菌（7.3%），3株为克柔念珠菌（2.7%），12株为热带念珠菌（11.0%）。还对获得的菌株进行了氟康唑和伊曲康唑的药敏试验。两种药物对大多数口腔分离株均显示出强烈的抑制作用。
