Karjalainen A, Pukkala E, Kauppinen T, Partanen T
Finnish Institute of Occupational Health, Department of Epidemiology and Biostatistics, Helsinki.
Cancer Causes Control. 1999 Feb;10(1):51-7. doi: 10.1023/a:1008845332422.
To study the asbestos-associated risk of lung cancer according to the histological type of cancer, the time of and time since diagnosis of asbestosis, the asbestos-associated risk for cancers other than lung cancer or mesothelioma, and the predictive value of asbestos-related pleural abnormalities as regards the risk of cancer.
Finnish patients with asbestosis (n = 1,376) or asbestos-related benign pleural disease (n = 4,887) notified as an occupational disease since 1964 were followed-up through the Finnish Cancer Registry for cancer in 1967-95.
Compared with the total cancer incidence in Finland, men with asbestosis had a raised risk of lung cancer (standardized incidence ratio [SIR] = 6.7; 95% confidence interval [CI] = 5.6-7.9), mesothelioma (SIR = 32, CI = 14-60) and cancer of the larynx (SIR = 4.2, CI = 1.4-9.8). The risk of lung cancer was similarly raised for all histological types of lung cancer (the highest in insulators) and did not change markedly over time of notification or duration of follow-up. Men with benign pleural disease had a raised risk of mesothelioma (SIR = 5.5, CI = 1.5-14) and a slightly elevated risk of lung cancer (SIR = 1.3, CI = 1.0-1.8). Among women with asbestosis, significant excess was found for lung cancer and mesothelioma.
Asbestosis and asbestos-related benign pleural disease seem to possess different predictive values as regards the risk of lung cancer.
根据癌症的组织学类型、石棉沉着病的诊断时间和确诊后的时间、除肺癌或间皮瘤以外的其他癌症的石棉相关风险，以及石棉相关胸膜异常对癌症风险的预测价值，研究与石棉相关的肺癌风险。
自1964年起被通报为职业病的芬兰石棉沉着病患者（n = 1376）或石棉相关良性胸膜疾病患者（n = 4887），在1967 - 1995年期间通过芬兰癌症登记处进行癌症随访。
与芬兰的总体癌症发病率相比，患有石棉沉着病的男性患肺癌（标准化发病率比[SIR]=6.7；95%置信区间[CI]=5.6 - 7.9）、间皮瘤（SIR = 32，CI = 14 - 60）和喉癌（SIR = 4.2，CI = 1.4 - 9.8）的风险升高。所有组织学类型的肺癌风险均有类似升高（绝缘工人中最高），且在通报时间或随访期间未发生明显变化。患有良性胸膜疾病的男性患间皮瘤的风险升高（SIR = 5.5，CI = 1.5 - 14），患肺癌的风险略有升高（SIR = 1.3，CI = 1.0 - 1.8）。在患有石棉沉着病的女性中，发现肺癌和间皮瘤有显著超额发病。
石棉沉着病和石棉相关良性胸膜疾病在肺癌风险方面似乎具有不同的预测价值。
