Gray G C, Kaiser K S, Hawksworth A W, Hall F W, Barrett-Connor E
Emerging Illness Division, Naval Health Research Center, San Diego, California 92186-5122, USA.
Am J Trop Med Hyg. 1999 May;60(5):758-66. doi: 10.4269/ajtmh.1999.60.758.
To investigate reports on war-related morbidity, 527 active-duty Gulf War veterans and 970 nondeployed veterans from 14 Seabee commands were studied in 1994 with a questionnaire, sera collection, handgrip strength, and pulmonary function testing. The questionnaire assessed postwar symptoms, war exposures, and screened for chronic fatigue syndrome, post-traumatic stress disorder, and psychological symptoms suggesting neurosis (Hopkins Symptom Checklist). Sera were tested with four nonspecific reactant assays: C-reactive protein, transferrin, ferritin, and haptoglobin. Gulf War veterans reported a higher prevalence for 35 of 41 symptoms, scored higher on psychological symptom scales, were more likely to screen for post-traumatic stress disorder, had lower handgrip strength, and had higher serum ferritin assay results. Numerous comparisons of these morbidity outcomes with 30 self-reported exposures demonstrated many associations, but no unique exposure or group of exposures were implicated. Morbidity data are consistent with other postwar observations, but the etiology for morbidity findings remains uncertain.
为调查与战争相关的发病率报告，1994年我们对来自14个海军建筑营司令部的527名海湾战争现役退伍军人和970名未参战退伍军人进行了研究，采用问卷调查、血清采集、握力测试和肺功能测试。问卷评估了战后症状、战争暴露情况，并对慢性疲劳综合征、创伤后应激障碍以及提示神经症的心理症状（霍普金斯症状清单）进行筛查。血清通过四种非特异性反应物检测进行检测：C反应蛋白、转铁蛋白、铁蛋白和触珠蛋白。海湾战争退伍军人报告称，41种症状中有35种的患病率更高，在心理症状量表上得分更高，更有可能筛查出创伤后应激障碍，握力更低，血清铁蛋白检测结果更高。将这些发病结果与30种自我报告的暴露情况进行的大量比较显示出许多关联，但没有发现单一的暴露因素或一组暴露因素与之相关。发病数据与其他战后观察结果一致，但发病结果的病因仍不确定。
