阿奇霉素联合利福平与单用阿奇霉素对实验性肺炎中肺组织肺炎衣原体清除效果的比较
Effect of azithromycin plus rifampin versus that of azithromycin alone on the eradication of Chlamydia pneumoniae from lung tissue in experimental pneumonitis.
作者信息
Wolf K, Malinverni R
机构信息
Department of Clinical Research, Inselspital, University of Bern, Bern, Switzerland.
出版信息
Antimicrob Agents Chemother. 1999 Jun;43(6):1491-3. doi: 10.1128/AAC.43.6.1491.
Abstract
Azithromycin, doxycycline, and rifampin, alone or in combination, were tested in vitro against Chlamydia pneumoniae AR-39. The combination of azithromycin plus rifampin showed the strongest activity and produced higher rates of eradication of C. pneumoniae from lung tissues than azithromycin alone in experimental mouse pneumonitis.
摘要
阿奇霉素、多西环素和利福平单独或联合使用，在体外对肺炎衣原体AR-39进行了测试。在实验性小鼠肺炎中，阿奇霉素加rifampin的组合显示出最强的活性，并且从肺组织中根除肺炎衣原体的比率高于单独使用阿奇霉素。
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2
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3
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4
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5
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6
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7
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8
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9
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10
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