阿奇霉素联合利福平与单独使用阿莫西林对小鼠肺炎衣原体肺炎慢性病程中病原体清除及炎症的影响。
Effect of azithromycin plus rifampin versus amoxicillin alone on eradication and inflammation in the chronic course of Chlamydia pneumoniae pneumonitis in mice.
作者信息
Bin X X, Wolf K, Schaffner T, Malinverni R
机构信息
Department of Clinical Research, Inselspital, University of Bern, Bern, Switzerland.
出版信息
Antimicrob Agents Chemother. 2000 Jun;44(6):1761-4. doi: 10.1128/AAC.44.6.1761-1764.2000.
Abstract
The effects of treatment with azithromycin plus rifampin (A+R), amoxicillin (A), or placebo (P) on the chronic course of experimental Chlamydia pneumoniae pneumonitis in mice were assessed by culture, PCR, and immunocytochemistry as well as by degree of inflammation in lung tissue. Eradication of the pathogen was significantly more frequent and inflammation in tissue was significantly reduced after treatment with A+R compared to after treatment with A or P. Combination therapy with azithromycin plus rifampin showed favorable effects in the chronic course of C. pneumoniae pneumonitis.
摘要
通过培养、聚合酶链反应（PCR）、免疫细胞化学以及肺组织炎症程度，评估阿奇霉素联合利福平（A+R）、阿莫西林（A）或安慰剂（P）治疗对小鼠实验性肺炎衣原体肺炎慢性病程的影响。与使用A或P治疗后相比，使用A+R治疗后病原体清除显著更频繁，组织炎症显著减轻。阿奇霉素联合利福平的联合疗法在肺炎衣原体肺炎慢性病程中显示出良好效果。
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本文引用的文献
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